Research Project 14

• Host institution: TECHNISCHE UNIVERSITÄT DRESDEN (TUD), Germany
  Researchgroup: Centre for Translational Bone, Joint and Soft Tissue Research
• Supervisor:  Dr. Anja Lode, e-mail: anja.lode@tu-dresden.de
• DC 14: NN
• Learn more about this position at EURAXESS 

Project Description

DC14 will develop hydrogel-based formulations loaded with bacteriophages to treat peri-implant mucositis and peri-implantitis. The project focuses on establishing in vitro biofilm models on titanium surfaces, identifying effective phages, exploring synergistic effects with antibiotics, and designing injectable composites with bioactive glass. This research aims to enhance biofilm removal and improve clinical outcomes for implant-related infections. 

Objectives

This PhD project aims to develop innovative hydrogel-based bacteriophage formulations to effectively combat oral biofilms on metallic implant surfaces in the future, thereby significantly improving the treatment of implant infections while maintaining implant integrity. Through a combination of microbiology, biomaterial science, and translational aspects, the doctoral candidate will evaluate bacteriophage formulations as anti-infective strategy with direct relevance to clinical applications in periimplantitis treatment.

Research activities include:

• Development and characterization of injectable, phage-loaded biomaterials based on (bio)polymers and bioactive glasses.
• Isolation, maintenance, and antibacterial testing of bacteriophages against oral bacterial species.
• Analysis of phage activity—both free and embedded in biomaterials—using in vitro biofilm models.

Training and mobility:

Research secondments at SHIELD partner institutions:

• University Hospital Regensburg (Germany)
• University of Oslo (Norway)
• Industrial partner (tbd)
• Participation in specialised training workshops and international conferences.

Expected Results