Research Project 9
Short description
This project deals with - Preventing bacterial infections in hearing implants using biocompatible materials with surface modifications: a cell culture study
- Host institution: KLINIKUM DER UNIVERSITÄT REGENSBURG (UHREG), Germany
Trauma Surgery - Supervisor: Prof. Dr. Martijn Riool, Martijn.Riool@klinik.uni-regensburg.de
- More contact: Dr. Raphaëlle Youf, Raphaelle.Youf@klinik.uni-regensburg.de
Gopala-Krishna Mannala, Gopala-Krishna.Mannala@klinik.uni-regensburg.de - DC 9: NN
Project Description
Short description: DC9 will focus on the biological evaluation of hydrogel-based system for the localised delivery of bacteriophages or antimicrobial peptides (AMPs) to treat bacterial infections associated with bone conduction hearing implants (BCHI). These systems will be applied to both metallic and polymeric surfaces, including components such as polymer healing caps and silicone-based transcutaneous devices.
The project will assess phage and AMP stability, release kinetics, and antibacterial efficacy against biofilm-forming pathogens using advanced in vitro models. In vivo studies in Galleria mellonella and mouse models will further evaluate therapeutic efficacy and host responses. Conducted in collaboration with clinical and biomaterials experts, the project aims to support the development of targeted antimicrobial therapies to improve infection management in BCHI patients.
Objectives:
Expected Results:
DC 9: A digital presentation of NN will come here
More information about the Doctoral positions at this EURAXESS's link