2. Research Project 10

Research Project 10

Research project
Active research
Project period
2025 - 2029
Project owner
GÖTEBORGS UNIVERSITET (UGOT), Sweden
Financier
EU - Horizon Europe, Marie Skłodowska-Curie Actions – Doctoral Networks, Grant Agreement No. 101226717
Area
Health and medicine
Science and Information Technology
Topic
Research

Short description

Antimicrobial peptides as infection control strategy in hearing bone conduction hearing implants.

Project Description

Short description: DC10 will identify novel biomarkers and develop effective antimicrobial strategies to prevent adverse tissue responses and infections related to hearing implants. This PhD study will first focus on identifying predictive biomarkers of adverse tissue responses by analysing human proteomics and microbiome data from the largest clinical cohort study on hearing implant inflammation. These biomarkers will be paired with clinical measures to improve diagnostic accuracy and personalised patient care. The student will also evaluate the cytocompatibility and antimicrobial efficacy of titanium surfaces functionalised with antimicrobial peptides (AMPs).

Learn more about this position at EURAWESS

Objectives:

This PhD project aims to identify biomarkers and develop effective antimicrobial strategies to prevent infection and inflammation related to hearing implants.

This project is part of the SHIELD doctoral network (Strategies for Healing Implant-associated infections and Enhancing Longevity in Devices), which addresses implant-associated infections through interdisciplinary and translational research.

Research activities include:

This PhD study will focus on microbiological and molecular profiling of human biosamples, obtained from the largest clinical cohort study on hearing implants, will be conducted to identify biomarkers linked to tissue complications. Biomarkers will be identified and paired with clinical measures to improve diagnostic accuracy and personalised patient care. The PhD student will also evaluate the cytocompatibility and antimicrobial efficacy of implant surfaces functionalised with antimicrobial peptides (AMPs) using experimental infection models to assess the biocompatibility and therapeutic potential of AMP-coated titanium and polymers in controlling infection and promoting tissue integration.  

Training and mobility:

  • Research secondments at SHIELD partner institutions:
    • The University of Birmingham (United Kingdom)
    • The Chancellor Masters and Scholars of The University of Cambridge (United Kingdom)
    • Amicoat AS (Norway)
  • Participation in specialised training workshops and international conferences

Expected Results


More information about the Doctoral positions at this EURAXESS's link

Last modified